The cat's meow would be getting a native port for CO2 like what Aspyr Media did for Civ 5 or what Feral Interactive did for Xcom EU - EW. I'd buy the game again, full price, if that happened.
If it wasn't for my wife's need for work software and my playing JA2 and now CO2 on Windows, I'd delete the windows partition in a heartbeat. My gaming needs aren't many and certainly not enough to hassle with wine, though I do play a couple an OLD Sid Meier's game (Silent Service) in dosbox.
Currently I'm having no luck setting permissions for CO2 so I can play it without running as admin. Don't know what's up with that as I've got all my other software setup so users can use it without problems. I'm going to delete the core engine, as that's all I've installed so far, and start from scratch. Probably user (my) error ;-].